NADPark Study: Key Findings Explained in Plain Language
NAD+ supplementation significantly increased brain NAD+ metabolites and was well-tolerated in a clinical study examining neurological biomarkers.
Study overview
Conducted by
Multi-center research team studying NAD+ neurological effects
Patients
Clinical cohort studying NAD+ brain metabolite changes
Duration
30 days
Published in
Cell Metabolism (preliminary data)
Year
2022
Key findings
Brain NAD+ metabolites increased measurably
Using MRS (magnetic resonance spectroscopy), researchers detected significant increases in brain NAD+ levels following supplementation, confirming the compound crosses the blood-brain barrier.
Well-tolerated with no significant adverse events
Participants reported no serious side effects. Mild flushing and warmth were the most common reports, consistent with known NAD+ effects.
Improvements in mitochondrial function markers
Blood biomarkers associated with mitochondrial energy production improved during the supplementation period.
Cerebral NAD+ levels correlated with cognitive metrics
Higher brain NAD+ levels were associated with better performance on cognitive assessments, though the study was not powered to prove causation.
What this means for you
This study provided evidence that NAD+ supplementation actually reaches the brain and increases measurable metabolites there. This matters because many of the benefits people report from NAD+ -- mental clarity, reduced brain fog, sharper focus -- depend on the compound reaching brain cells. The study confirms it does.
Limitations
This was a relatively small study and not a large-scale RCT. The duration was short (30 days). The cognitive correlations were observational, not causal. Larger, longer trials are needed to confirm the neurological benefits.
See if this compound is right for your goals
Take a 2-minute quiz. Get a personalized protocol.